Lindsey Nelson Stadium was a launch pad over two games. James Madison hit four home runs in the first game, and Tennessee tied a program record with seven in game two.
Tennessee took game two of the series against Vanderbilt on Saturday. The winner of game three will have sole possession of first place in the SEC East.
The Vols move to 9-0 with a convincing midweek game win against UNC Asheville.
Tennessee won its weekend series with the Crimson Tide in Knoxville to snap a three-year streak.